West RegionalIN BRIEFGame to watch: No. 1 Wisconsin vs. No. 8 Oregon (87.3) at 7:45 p.m. EDT on TruTVIN DEPTHWisconsin (87 percent) vs. OregonPlayer to watch: Frank Kaminsky, WisconsinOregon’s offense — far and away the strength of the team — came to the rescue against Oklahoma State in the round of 64 as the Ducks shot 55 percent from the floor to outgun the Cowboys in a 79-73 win. But securing enough stops to beat Wisconsin might be a struggle for the defensively challenged Ducks. According to Ken Pomeroy’s ratings, Wisconsin easily owns the best offense in the country, a unit primed to take advantage of Oregon’s weak shot defense and inability to force turnovers. The Ducks also lack the risky traits that sometimes help heavy underdogs chance their way into upsets. But one path the Ducks might navigate to victory is to force the tempo and make the Badgers play at their pace. Oregon had the 33rd-fastest offense in the country this season (as measured by seconds per possession), while Wisconsin had the third-slowest. While Saturday’s top-billed matchups (specifically, Arizona-Ohio State and Kentucky-Cincinnati) looked sexier on paper than any in store on Sunday, day No. 2 of the round of 32 offers some solid games of its own — as well as fewer sleepers. Keep a particular eye on the trio of 2-versus-7 matchups, each of which should be reasonably competitive by the standards of this round.Here’s what else to look for:South RegionalGame to watch: No. 1 Duke vs. No. 8 San Diego State (a harmonic mean of 88.0) at 2:40 p.m. EDT on CBSUpset alert! No. 7 Iowa (27 percent win probability) vs. No. 2 Gonzaga at 7:10 p.m. EDT on TBSIN DEPTHDuke (85 percent win probability) vs. San Diego StatePlayer to watch: Jahlil Okafor, DukeAfter taking care of Robert Morris with ease in its opener, Duke moves on to face the slow-paced, defensively focused Aztecs. San Diego State has a tall team that ranks among the nation’s best at limiting opponents’ shooting efficiency and keeping them from getting to the line. But watch for Duke’s offensive rebounding (spearheaded by All-Everything center Jahlil Okafor) to offset some of SDSU’s defensive advantage. And when the Aztecs have the ball, scoring might be an ordeal. Neither of San Diego State’s two go-to guys on offense — Winston Shepard and Dwayne Polee — could even match the Division I average for efficiency when they ended an Aztec possession, a trend that figures to continue against a solid Blue Devils defense. East RegionalIN BRIEFGame to watch: No. 2 Virginia vs. No. 7 Michigan State (89.5) at 12:10 p.m. EDT on CBSUpset alert! No. 5 Northern Iowa (55 percent) vs. No. 4 Louisville at 9:40 p.m. EDT on TBSIN DEPTHVirginia (72 percent) vs. Michigan StatePlayer to watch: Anthony Gill, VirginiaVirginia didn’t exactly look dominant against a stubborn Belmont team Friday, and now the Cavaliers must face an even tougher opponent in Michigan State. The Spartans have the talent to stick with Virginia — they’d have a 37 percent chance of the upset here if we based our prediction on preseason ratings alone — and their coach is familiar with deep tournament runs. Plus, Virginia operates its offense at a veritable crawl, slowing down the game and inviting the kind of variance that can prove deadly for a favorite. But other than their snail-like pace, the Cavaliers play a sturdy style as upset-proof as any, relying primarily on two-point shooting, ball security, rebounding, and an old-fashioned big, tough interior defense. It all makes for a team with few clear weaknesses, something Michigan State will likely learn the hard way.Check out FiveThirtyEight’s March Madness predictions. Midwest RegionalIN BRIEFGame to watch: No. 2 Kansas vs. No. 7 Wichita State (87.6) at 5:15 p.m. EDT on CBSUpset alert! No. 5 West Virginia (55 percent) vs. No. 4 Maryland at 8:40 p.m. EDT on TNTIN DEPTHKansas (57 percent) vs. Wichita StatePlayer to watch: Fred VanVleet, Wichita StateWichita State’s offense clicked in the second half of its victory over Indiana on Friday, but the points may not come as easily against a strong Kansas defense that ranks ninth nationally in Ken Pomeroy’s schedule-adjusted ratings. The game may come down to whether Wichita State can execute its pick-and-roll — according to Synergy Sports, the Shockers’ pick-and-roll ball-handling efficiency ranked in the 93rd percentile of Division I schools; the Jayhawks’ defense was in the 85th percentile at stopping the play. At the other end, it’s worth watching whether the more interior-focused Kansas offense can adapt to take advantage of a Wichita State defense that dares opponents to move the ball around and shoot from the outside.